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New reports: IBS and Alzheimer's disease

Learn about the latest discoveries, explore your data and improve your health!

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Learn about the latest discoveries, explore your data and improve your health!
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Hey Explorer,

This week’s update includes two new reports based on two recent studies. The first report examines the genetics of Irritable bowel syndrome (IBS) and the second report looks at predisposition to Alzheimer's disease. Both studies also implicated genes that you can examine in detail with the exploration tools that are available with our Deep and Ultra Deep Whole Genome Sequencing! Looking for actionable advice? Read on and learn what you can do to reduce IBS symptoms

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Irritable bowel syndrome: Irritable bowel syndrome (IBS) is a chronic condition that can cause abdominal cramping, bloating, and a change in bowel habits. Some people with the disorder have constipation, others have diarrhea, and some go back and forth between the two. Although IBS can cause a great deal of discomfort, it does not harm the intestines. Overall, IBS is a common condition thought to affect between 10 and 15% of people in the United States. This genome-wide association study of over 486,000 individuals of European ancestry sought to better understand how genetics affect an individual’s predisposition to developing IBS. [Published on November 5th, 2021Got your results already? Log in and view your new report! 

Alzheimer's disease: The brain is made up of billions of nerve cells that work to connect and communicate to one another. In Alzheimer’s disease, these connections are progressively lost and can seriously affect a person's ability to carry out daily activities. Alzheimer’s disease usually begins after the age of 60, and the risk of developing the condition goes up as an individual gets older. Though age is associated with Alzheimer’s disease, genetics also contribute to an individual’s predisposition to the condition. In order to better understand the likelihood of developing Alzheimer’s disease related to the genome, scientists studied the genomes of over 1.1 million individuals of European ancestry. [Published on September 7th, 2021] Got your results already? Log in and view your new report!

Are you still waiting for your results? We are making the content of the reports available for free on our blog!

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Researchers identified 6 regions of the genome associated with IBS. Genes located in these regions, including NCAM1, CADM2, and PHF2, suggest a deep connection between the brain and the gut. For example, genetic variants in CADM2 were linked to various mental health issues while the NCAM1 encodes a protein that is used by the rabies virus to enter nerve cells. 

You can use our genome browser and gene analysis tools to examine NCAM1, CADM2, and PHF2 genes and any other of the ~20,000 genes in your genome! Simply log in, open the gene analysis tool and search for the three gene names.

Follow Science and Improve Your Health

IBS symptoms can often be controlled by managing stress and by making changes in your diet and lifestyle. Try to:

  • Avoid foods that trigger your symptoms
  • Eat high-fiber foods
  • Drink plenty of fluids
  • Exercise regularly
  • Get enough sleep

Source: https://www.mayoclinic.org/diseases-conditions/irritable-bowel-syndrome/diagnosis-treatment/drc-20360064

 

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