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New reports: Myosthenia gravis and Asthma-COPD overlap syndrome

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Hey Explorer,

This update includes two new reports based on two recent studies. The first report examines the genetics of Myosthenia gravis and the second report looks at predisposition to Asthma-COPD overlap syndrome. Both studies also implicated genes that you can examine in detail with the exploration tools that are available with our Deep and Ultra Deep Whole Genome Sequencing! Looking for actionable advice? Read on and learn what you can do to reduce the symptoms for Asthma-COPD overlap syndrome

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Myasthenia gravis: Myasthenia gravis is an autoimmune neuromuscular disease. It occurs when the immune system mistakenly attacks and damages the connections between muscles and nerves. This leads to muscular weakness across the body, and can also cause double vision, a propensity to falling, difficulty speaking, and shortness of breath. This genome-wide association study examined more than 38,000 individuals of European ancestry and discovered 6 genetic variants associated with myasthenia gravis. [Published on February 1st, 2021Got your results already? Log in and view your new report! 

Asthma-COPD overlap syndrome: Asthma is a long-term disease of the lungs. It causes the airways to get inflamed and narrow, which makes it hard to breathe. Chronic obstructive pulmonary disease (COPD) describes a collection of lung diseases that cause breathing problems due to an obstructed airflow. Most people with asthma will not develop COPD, and many people with COPD don’t experience asthma. However, some people are susceptible to developing both diseases at once. This condition, known as asthma-COPD overlap syndrome, can seriously affect an individual's ability to breathe, with symptoms worse than either asthma or COPD alone. To discover genetic variants that may contribute to an individual’s susceptibility to developing asthma-COPD overlap syndrome, this study examined over 48,000 individuals of European ancestry. [Published on December 21st, 2021] Got your results already? Log in and view your new report!

Are you still waiting for your results? We are making the content of the reports available for free on our blog!

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The researchers identified 8 genetic variants associated with Asthma-COPD overlap syndrome. One such variant was located inside the TSLP gene which encodes a protein that plays a role in inflammation. The variant has previously been associated with asthma, suggesting asthma and asthma-COPD overlap syndrome may have related causes.

You can use our genome browser and gene analysis tools to examine the TSLP gene and any other of the ~20,000 genes in your genome! Simply log in, open the gene analysis tool and search for the three gene names.

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Asthma triggers often include allergens, such as pollen, dust mites, cockroaches, molds and animal dander. Allergens can make COPD symptoms worse. And if left untreated, allergies and asthma can increase the chances for COPD in certain individuals.

Smoking is the greatest risk factor for developing COPD. The most important thing you can do for your health is to stop smoking.



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