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New weekly reports: Migraines and testicular tumors

Learn about the latest discoveries, explore your data and improve your health!

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Learn about the latest discoveries, explore your data and improve your health!
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Hey Explorer,

After a summer break, we are now resuming our weekly updates! This week’s update includes two new reports based on two recent studies. The first report examines the genetics of migraines and the second report looks at predisposition to testicular tumors. Both studies also implicated genes that you can examine in detail with the exploration tools that are available with our Deep and Ultra Deep Whole Genome Sequencing! Looking for actionable advice? Read on and learn what you can do against migraines

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New DNA Reports in the Nebula Library
(available with Deep and Ultra Deep Whole Genome Sequencing;
partially available with DNA data uploads)

Migraines: A migraine is a headache characterized by throbbing head pain, usually located on one side of the head. It is often accompanied by nausea, vision troubles, and sensitivity to light and/or sound. Women are three times more likely to experience migraines than men. To identify genetic factors linked to migraines, this study examined almost 900,000 individuals of European ancestry. The scientists identified 73 regions of the genome associated with an individual’s risk of migraines, 40 of which were newly identified.  [Published on July 22rd, 2021Got your results already? Log in and view your new report! 

Testicular tumors: The testicles are two small, egg-shaped glands located close to the penis. Testicles contain many specialized types of cells, such as germ cells, that contribute to the production of sperm. While testicular cancer is relatively uncommon, affecting up to 90,000 men per year in the US, it is the most common cancer in men younger than 35. Overall, about 95 percent of testicular cancers begin in the sperm-producing germ cells. To better understand genetic factors that contribute to an individual’s risk of testicular germ cell tumors (TGCT), this study examined nearly 190,000 men of European ancestry. The research identified 78 regions of the genome associated with TGCT, 22 of which were novel. [Published on July 23rd, 2021] Got your results already? Log in and view your new report!

Are you still waiting for your results? We are making the content of the reports available for free on our blog!

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(available with Deep and Ultra Deep Whole Genome Sequencing only)

Dive deeper into this week's reports with our exploration tools for your Whole Genome Sequencing data!

One of the genes implicated in migraines was TGFB1. This gene encodes a secreted protein that binds to various TGF-beta receptors which can lead to cell proliferation, differentiation and growth. TGFB1 is also frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease, a skeletal condition that is characterized by abnormally thick bones in the arms, legs, and skull. 

You can use our genome browser and gene analysis tools to examine the TGFB1 gene and any other of the ~20,000 genes in your genome! Simply log in, open the gene analysis tool and search for the three gene names.

Follow Science and Improve Your Health

While you may have inherited a predisposition to migraines, there are many lifestyle changes that you can implement to reduce the frequency and severity of migraine episodes.

  • Sleep. Go to bed and get up about the same time every day, including on weekends and holidays. When you hit the sack at random times or you get too much or too little shut-eye, that can trigger a headache.
  • Exercise regularly. Overdoing a workout may trigger a headache for some people, but research suggests regular, moderate aerobic exercise may make migraines shorter, less severe, and happen less often for many people.
  • Eat regular meals. A drop in blood sugar can set off a migraine, so keep it steady by not skipping meals. Also, drink plenty of water to avoid dehydration, which can trigger the headaches.
  • Limit stress. Tension's a common trigger. So, take time each day to relax. You could listen to calming music, take a short walk, meditate and do yoga.


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