Your gut worked overtime this weekend

What happens inside when you eat more than usual (and how to bounce back fast)

This email was sent

July 6, 2026 12:27pm EDT

Is this your brand on Milled? Claim it.

Matte tone:

Casa de Sante

Gut-Friendly Nutrition

Digestive Health|Protein Powders|GLP-1 Support|Hormone Balance

Your gut worked overtime this weekend

Casa de Santé

Gut Health, Physician Formulated

Holiday Digestive Reset

Your Gut Worked Overtime This Weekend

Hi friend,

One of my patients texted me Tuesday morning after last July 4th: she'd eaten clean for six weeks on Ozempic, then the long weekend happened. Two cookouts, a few drinks, way too many chips. Suddenly nothing felt right.

She wasn't imagining it, and she hadn't ruined anything.

Three days of richer, higher-volume meals asked her digestive system to produce 2 to 3 times more enzymes than it had been making on her smaller GLP-1 portions. Her pancreas got a workload it wasn't prepared for.

Why This Hits Harder on GLP-1 Medications

Your body adjusts enzyme production to match what you eat. Weeks of smaller meals on a GLP-1 medication means your pancreas scales back. Published data in BMJ Gut confirms GLP-1 receptor activation reduces gastric acid output by 67% and lipase, your fat digesting enzyme, by 36%.

Then a holiday weekend arrives: burgers, potato salad, dessert. Your enzyme supply hasn't caught up to the sudden demand. The result is bloating, heaviness, gas, and that "brick in my stomach" feeling that can last 2 to 4 days after the holiday ends.

Two Things That Help This Week

Take a digestive enzyme before your three biggest meals. A broad spectrum enzyme with lipase, protease, and amylase bridges the gap between what your body produces and what your meals require. Clinical data from NDS (2024, NCT05520411) showed 68% less abdominal distension at 90 minutes in adults taking a multi-enzyme blend with meals.

Eat protein first at every meal for the next 5 days. Protein triggers the strongest enzyme and bile response. Starting with protein primes your digestive system before carbs and fats arrive, and it also helps you get back to your normal portion sizes faster.

That patient kept a digestive enzyme in her bag for the rest of the summer. Her exact words in September: "I stopped dreading weekends."

You don't need to avoid cookouts. You need to support the system that processes them.

Browse Digestive Enzymes Collection