Which MISMO supplements can you take together?

Morning vs night — here's what we'd actually recommend.

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June 1, 2026 8:32pm EDT

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SUPPLEMENTS

What Is Supplement Stacking?

More supplements doesn't always mean better results — but the right combinations, taken at the right time, can make a real difference. If you've ever wondered whether your MISMO supplements work together or against each other, here's the run down.

YOUR MORNING STACK — ENERGY, PERFORMANCE & PROTECTION

Start your day with Creatine, MSM, and Vitamin C.

Creatine is one of the most researched supplements in the world — it supports cellular energy production and has been shown in multiple studies to reduce markers of muscle damage and inflammation following exercise.

MSM pairs naturally with creatine: while creatine supports energy and muscle repair, MSM delivers sulphur to connective tissue and has been shown to reduce post-exercise soreness and support the body's antioxidant defences. Take both with breakfast.

Your Vitamin C fits here too — it plays a direct role in the enzymatic steps needed for collagen synthesis, and research shows that taking Vitamin C alongside collagen (even earlier in the day) can meaningfully improve how well the body uses it.

THE POWER PAIRING — COLLAGEN & VITAMIN C

These two belong together. Vitamin C is required for the body to produce and cross-link collagen fibres — without adequate Vitamin C, collagen synthesis is significantly impaired. A randomised crossover study published in the American Journal of Clinical Nutrition found that Vitamin C-enriched gelatin taken before activity increased markers of collagen production in the blood.

The practical takeaway: take your Collagen and Vitamin C at the same time, ideally in the morning or around any exercise. You don't need massive doses — research suggests 50–100mg of Vitamin C alongside your collagen is sufficient to support the synthesis process.

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YOUR EVENING SUPPLEMENT — WIND DOWN & RECOVER

Magnesium Glycinate is your night-time supplement. Magnesium acts as a natural antagonist to excitatory signals in the nervous system — it enhances GABA activity (the neurotransmitter that helps your brain slow down) and supports melatonin production.

A clinical trial found that magnesium supplementation before bed led to significant improvements in sleep onset, sleep efficiency, and early morning cortisol levels compared to placebo. Glycinate is the preferred form for this purpose because glycine itself is a calming amino acid that complements magnesium's effects. Take it 30–60 minutes before bed, consistently. That's when it earns its place.

You don't need to take everything at once or overhaul your whole routine. Start with one stack — morning or evening — and build from there. Consistency over time is where the results come from.

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Which MISMO supplements can you take together?

Morning vs night — here's what we'd actually recommend.

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