Loss of the Y chromosome in tumours could be ‘contagious’

Hello Nature readers,
Today we learn that Chinese temples provide refuge for endangered trees, hear that the loss of the Y chromosome in tumours could be ‘contagious’ and consider the impact of Trump’s latest policies on US science.

Ancient trees protected in Chinese temples

Buddhist and Taoist temples in China are providing a refuge for trees — the oldest of which has been growing for 2,000 years. A study of nearly 50,000 trees, each more than a century old, described nearly 61 threatened species, eight species that were found only on temple grounds and the only existing individual of Carpinus putoensis.

Iron-deficient male mice can grow ovaries

Male mouse fetuses can develop female organs in utero if their mother is iron deficient during pregnancy. When pregnant mice were given a molecule that sequesters iron, or their embryos had genetic tweaks that disrupted their iron uptake, a handful of pups with XY chromosomes in their litters grew ovaries. The findings could have implications for medical advice about iron intake during pregnancy, says molecular geneticist Vincent Harley. But as most embryos developed typical sexual characteristics, there must be other key factors that influence sex, he adds.

A long-sought alternative to opioids for pain

A young street performer in Pakistan who became famous for not feeling pain. A group of people in Alabama who felt excruciating burning in response to the slightest heat. Both had mutations in the SCN9A gene, which acts on the function of the tiny sodium channel called Na_V1.7 that helps to conduct electrical signals in pain-sensing nerves. “We all went crazy, because people without Na_V1.7 were pain-free but otherwise normal,” says molecular neurobiologist John Wood. “It was unbelievably exciting.” Eventually, this discovery helped to kick off the development of a promising new painkiller: suzetrigine. In January, the drug (marketed as Journavx), became the first new non-opioid painkiller in more than twenty years to receive approval for acute-pain treatment from the US Food and Drug Administration.

Don’t let your default be ‘free’

The situation will be familiar to many scientists: behavioural scientist Dritjon Gruda was asked to give a seminar, but when he quoted his fee, he was met with radio silence. Researchers often spend hours doing unpaid work, but there are ways to force you and any prospective partner to treat your labour as professional work, Gruda writes. Keep a tangible list of services and fees handy, bring up payment as soon as possible and seek support from your institution. “We need to break the illusion that all other academics are giving away their work for free,” writes Gruda.