References

1. O’Neill CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. BioEssays. 2016;38(11):1167-1176. doi:10.1002/bies.201600008

2. Salem I, Ramser A, Isham N, Ghannoum MA. The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol. 2018;9(JUL):1-14. doi:10.3389/fmicb.2018.01459

3. Yan HM, Zhao HJ, Guo DY, Zhu PQ, Zhang CL, Jiang W. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018;45(10):1166-1171. doi:10.1111/1346-8138.14586

†Optibac is the brand of friendly bacteria supplements most trusted & recommended by UK consumers. See website T&Cs for survey details, 1,000 people, August 2025.

†An independent, nationally representative survey conducted in August 2025 of 1,000 British and 500 Irish women aged 25-70 who had purchased a health supplement in the last 12 months. Respondents were asked their gender and parental status, and then to select the brand they most trust, from the 5 most googled brands of probiotic supplements across the UK and Ireland in June 2025.

⁰Our range has more scientific research behind the strains than other UK & Irish brands.

Wren Laboratories | Unit 21 - 22 Mayfield Avenue Industrial Estate, Andover, Hampshire SP11 8HU United Kingdom

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